|
426 |
3P
|
3P9L37D |
High |
View
Click on a Luminex® HLA allele that shares the eplet 3P to view it at pHLA3D
DQB1*06:01,
|
|
|
|
DQB1*06:01
|
View (1)
List of Luminex® HLA alleles
DQB1*06:01,
List of all (Luminex® or not) HLA alleles
DQB1*06:01,
|
|
427 |
3S
|
3S |
High |
View
Click on a Luminex® HLA allele that shares the eplet 3S to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*04:01,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
|
|
|
|
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (39)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:12, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:12, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:20, DQB1*06:33, DQB1*06:37, DQB1*06:44, DQB1*06:46, DQB1*06:48, DQB1*06:49,
|
|
428 |
9F
|
9F |
Low |
View
|
|
|
|
DQB1*04:01, DQB1*04:02, DQB1*06:02
|
View (26)
List of Luminex® HLA alleles
DQB1*04:01, DQB1*04:02, DQB1*06:02,
List of all (Luminex® or not) HLA alleles
DQB1*03:30, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*06:02, DQB1*06:10, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:19, DQB1*06:20, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:29, DQB1*06:33, DQB1*06:37, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50,
|
|
429 |
9Y
|
9Y |
Low |
View
Click on a Luminex® HLA allele that shares the eplet 9Y to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
|
|
|
|
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (95)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:04, DQB1*04:05, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:11, DQB1*06:12, DQB1*06:17, DQB1*06:18, DQB1*06:21, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:34, DQB1*06:36, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:44, DQB1*06:45, DQB1*06:52,
|
|
430 |
13GM
|
13G14M |
Very Low |
View
Click on a Luminex® HLA allele that shares the eplet 13GM to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:02,
DQB1*03:03,
DQB1*04:01,
DQB1*04:02,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
|
|
|
|
DQB1*02:01, DQB1*02:02, DQB1*03:02, DQB1*03:03, DQB1*04:01, DQB1*04:02, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (79)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:02, DQB1*03:03, DQB1*04:01, DQB1*04:02, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:02, DQB1*03:03, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:15, DQB1*03:17, DQB1*03:18, DQB1*03:20, DQB1*03:23, DQB1*03:25, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:43, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:50, DQB1*06:52,
|
|
432 |
23L
|
23L |
High |
View
Click on a Luminex® HLA allele that shares the eplet 23L to view it at pHLA3D
DQB1*04:01,
|
|
|
|
DQB1*04:01
|
View (5)
List of Luminex® HLA alleles
DQB1*04:01,
List of all (Luminex® or not) HLA alleles
DQB1*04:01, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08,
|
|
433 |
23R
|
23R |
High |
View
Click on a Luminex® HLA allele that shares the eplet 23R to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
|
|
|
|
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (120)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
|
|
433 |
26L
|
26L |
Intermediate |
View
|
|
|
|
DQB1*02:01, DQB1*02:02, DQB1*03:02, DQB1*03:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (77)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:02, DQB1*03:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:02, DQB1*03:03, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:11, DQB1*03:12, DQB1*03:15, DQB1*03:18, DQB1*03:20, DQB1*03:23, DQB1*03:25, DQB1*03:26, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:43, DQB1*04:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
|
|
434 |
30H
|
30H |
Intermediate |
View
|
|
|
|
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:03, DQB1*06:04
|
View (37)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:03, DQB1*06:04,
List of all (Luminex® or not) HLA alleles
DQB1*03:38, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:03, DQB1*06:04, DQB1*06:07, DQB1*06:08, DQB1*06:14, DQB1*06:17, DQB1*06:21, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:34, DQB1*06:36, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:44, DQB1*06:52,
|
|
436 |
37YA
|
37Y38A |
High |
View
Click on a Luminex® HLA allele that shares the eplet 37YA to view it at pHLA3D
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*04:01,
DQB1*04:02,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
|
|
|
|
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (98)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:05, DQB1*05:11, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
|
|
436 |
37YV
|
37Y38V |
High |
View
|
|
|
|
DQB1*05:01, DQB1*05:02, DQB1*05:03
|
View (14)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03,
List of all (Luminex® or not) HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:10, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:28,
|
|
437 |
45EV
|
45E46V47Y |
High |
View
|
Yes
|
45EV on DQB1*03:01, *03:19
This serum has also weak reactivity with 55PP
|
|
Schreuder, G. M., H. Maeda, et al. (1986). "TA10 and 2B3, two new alleles in the HLA-DQ region recognized by monoclonal antibodies." Human Immunology 16(2): 127-136. Mouse mAb A10/13 detects the TA10 specificity on PBL. The DQw3 related TA10 and the 2B3-defined specificity appeared to be in perfect Hardy-Weinberg equilibrium and they are unrelated to the serological DQ specificities.
Kenter, M. J. H., J. D. H. Anholts, et al. (1989). "Umambiguous Typing for HLA-DQ TA10 and 2B3 Specificities Using Specific Oligonucleotide Probes." Hum Immunol 24: 65-73. Mouse mAb TA10 reacts with DQ3.1 molecules that share the 45E residue.
Maeda, H., R. Hirata, et al. (1986). "Multiple epitopes on a single DQ molecule from the DQw3-carrying haplotypes." Tissue Antigens 28(3): 136-145. Mouse mAb TA10 and IIB3 detect two new DQw3-related polymorphisms other than the conventional DQw1-w3 alleles. The TA10 specificity is in linkage disequilibrium with DR5 and weakly associated with DR4. The IIB3 specificity is in linkage disequilibrium with DR2, DR4, DRw9 and DRw13. Molecular and topological analysis has revealed that both TA10 and IIB3 determinants were expressed on the same DQ3 molecule.
Navarrete et al, Genetic Diversity of HLA – Functional and Medical Implications, vol. 1, D. Charron (Ed), pp 11-17, 1997: Mouse mAb PLM2 (12w619) and TA10 (12w620) react with HLA-DQB1*03:01 in CDC assays in 12th IHWS.
Deng, C. T., J. Cai, et al. (2006). "HLA Class II DQ Epitopes." Clinical Trasnplants 2006: 115-122.Five mouse mAb positive with HLA-DQB1*03:01 Equivalent to TerEp #2005.
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from a DQB1*03:01 mismatched transplant patient who typed as DQB1*03:02, DQB1*05:03 and showed antibodies to a DQB epitope defined by 45E and corresponding to Terasaki’s epitope # 2005.
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DQB1*03:01, DQB1*03:19
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View (17)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:19,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:04, DQB1*03:09, DQB1*03:13, DQB1*03:16, DQB1*03:19, DQB1*03:21, DQB1*03:22, DQB1*03:24, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:35, DQB1*03:36, DQB1*03:42, DQB1*03:44, DQB1*06:35,
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438 |
45G
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45G |
High |
View
Click on a Luminex® HLA allele that shares the eplet 45G to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:02,
DQB1*03:03,
DQB1*04:01,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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DQB1*02:01, DQB1*02:02, DQB1*03:02, DQB1*03:03, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (107)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:02, DQB1*03:03, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:02, DQB1*03:03, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:14, DQB1*03:15, DQB1*03:17, DQB1*03:18, DQB1*03:20, DQB1*03:23, DQB1*03:25, DQB1*03:26, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:43, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
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440 |
45GV
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45G46V |
High |
View
Click on a Luminex® HLA allele that shares the eplet 45GV to view it at pHLA3D
DQB1*03:02,
DQB1*03:03,
DQB1*04:01,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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Yes
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45GV on DQB1*03:02/03, *04, *05, *06
Schreuder, G. M., H. Maeda, et al. (1986). "TA10 and 2B3, two new alleles in the HLA-DQ region recognized by monoclonal antibodies." Human Immunology 16(2): 127-136. Mouse mAb 2B3 detects a specificity on PBL that is different from the DQw3-related TA10 determinant. The two specificities appeared to be in perfect Hardy-Weinberg equilibrium and are unrelated to the serological DQ specificities.
Radka, S. F., K. A. Nelson, et al. (1989). "HLA-DQw3-related determinants: analysis of subunit and spatial relationships." Human Immunology. 25(4): 225-236. Mouse and rat mAbs induced by DQw3,TA10+ or DQw3,TA10- antigens were studied by Western blotting and for their ability to inhibit the binding of fluoresceinated antibodies on either TA10+ or TA10- DQw3 haplotypes. The data suggest multiple epitopes on DQ3 and that their spatial relationship is influenced by amino acid residues in positions 45 and 57 of DQB chains. The DQw3+, TA10--induced Gs159.1 was specific for TA10. The DQw3+, TA10--induced GS285-2B6.7 and GS295-3E5 as well as the DQw3+, TA10+-induced SFR20-DQW3 are all specific for DQw3 although the latter showed weaker reactions with DQw3+, TA10- antigens. The DQ4-induced GS200.1 reacted with DQw1, DQw3.2, DQw3.3 and DQw4 similar to IIB3.
Kenter, M. J. H., J. D. H. Anholts, et al. (1989). "Umambuous Typing fro HLA-DQ TA10 and 2B3 Specificities Using Specific Oligonucleotide Probes." Hum Immunol 24: 65-73. Mouse mAb 2B3 reacts with DQ1, DQ3.2/3 and DQ-blank (DQ4?) molecules that share the 45G46V47Y residue combination.
Nordwig, H., W. W. Kwok, et al. (1991). "Identification of the amino acid residues contributing to monoclonal antibody-defined DQw1 epitopes." Human Immunology. 31(2): 81-85. immunoblotting and flow cytometry an epitope on B-LCL in position 45G46V47Y which is shared between all DQB alleles except DQ7 which has 45G46V47E and DQ2 which has 45G46E47F. They did not react with mutated DQw8 with a G45E substitution. None of these mAbs reacted by immunoblotting and flow cytometry with PBL nor did they bind to living cells but they reacted partially to denatured DQ molecules on such cells.
Viken, H. D., E. Thorsby, et al. (1995). "Characterization and epitope mapping of four HLA class II reactive mouse monoclonal antibodies using transfected L cells and human cells transfected with mutants of DQB1*0302." Tissue Antigens 45(4): 250-257. Three HLA-DQ8-induced mouse mAbs, 13B6, 17F8 and 19A1, bound to all DQ1, 4, 8 or 9 positive B-lymphoblastoid cell lines (B-LCLs) and transfectants tested, i.e. cells carrying the DQB1 genes 0302-3, 0401-2, 0501-3, 0601-4 and 0609 irrespective of the accompanying DQA1 gene. These DQB1 genes code for the shared amino acids GVY in position 45-47 of the DQ beta chain. DQ1+4+8+9 specific (IIB3) and DQ3 specific (IVD12) reference mAbs inhibited binding of all three mAbs. Testing with mutated DQB1*0302 with residue substitutions in various positions indicated involvement of 45G in the epitopes of all three mAbs. This reactivity pattern correlates with a shared sequence of shared RFDSDVGE in position 39-46 of DQ.
Petersen, J. S. and T. Dyrberg (1992). "Production of epitope specific monoclonal IgG antibodies to HLA class II molecules by combining in vivo and in vitro immunization." Journal of Immunological Methods 151(1-2): 15-26. mAbs were generated from mice immunized with synthetic peptides representing allelic HLA-DQw7 and HLA-DQw8 beta chain sequences One mAb to a peptide representing DQw8 beta position [49-60] specifically recognised the DQw8 beta chain. Three mAbs to a peptide representing DQw8 beta position [39-52] specifically recognised an epitope consisting of Gly-Val-Tyr in position 45-47, i.e., all DQ beta alleles except DQw7 beta (position 45-47: Glu-Val-Tyr) and DQw2 beta (position 45-47; Gly-Glu-Phe).
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from two DRB1*06:03 mismatched transplant patients showed antibodies to a DQB epitope defined by 45G+46V and corresponding to Terasaki’s epitope # 2010.
This DQB1*06:02 induced antiserum reacted with all 45GV-carrying DQB alleles
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DQB1*03:02, DQB1*03:03, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (99)
List of Luminex® HLA alleles
DQB1*03:02, DQB1*03:03, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:02, DQB1*03:03, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:14, DQB1*03:15, DQB1*03:17, DQB1*03:18, DQB1*03:20, DQB1*03:23, DQB1*03:25, DQB1*03:26, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:43, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
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441 |
46VY
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46V52P28T |
High |
View
Click on a Luminex® HLA allele that shares the eplet 46VY to view it at pHLA3D
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*04:01,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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Yes
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46VY on all DQB1 alleles except DQB1*02:01/02
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Previously called 46VY2 Non-DQB2 alleles share four unique polymorphic residues: 28T, 46V and 52P (28T is not visible)
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Marsh, S. G. and J. G. Bodmer (1989). "HLA-DR and -DQ epitopes and monoclonal antibody specificity." Immunology Today 10: 305-312. Mouse mAb HU11 (10W3097) reacts with DQB1 sharing 46V47Y
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from two transplant patients who typed as DQB1*02:01,- (the mismatch was DQB1*05:03) and DQB1*02:01,DQB1*02:02 (the mismatch was DQB1*03:01). Both showed antibodies to a DQB epitope defined by 52P and corresponding to Terasaki’s epitope # 2003
Deng et al, Clinical Transplants 2006, pp 115-122: Two mouse mAbs react with HLA-DQB1*03:01, *03:02, *03:03, *04:01, *04:02, *05:01, *05:02, *06:01, *06:02 Equivalent to TerEp #2003.
Deng et al, Transplantation 86: 452-459, 2008: Case 1 serum eluate (absorbed with DQ7 cells) positive with DQ4, 5, 6, 7, 8, 9
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DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (117)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
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442 |
52LL
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52L55L28S30S37I |
High |
View
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Yes
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52LL on DQB1*02:01 and DQB1*02:02
52LL was previously called 45GE3. It may represent three distinct eplets unique on DQ2 and defined by polymorphic residues 52L+55L and 28S+30S and 37I.
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Pistillo MP, Hämmerling U, Dupont B, Ferrara GB. In vitro production of a human HLA alloantibody of restricted specificity (DQw2) via Epstein-Barr virus transformation. Hum Immunol. 1986 Jan;15(1):109-17. This paper describes the in vitro production of the human alloantibody 454A.C5 with HLA-DQw2 specificity produced by a stable EBV-transformed cell line. Immune B cells for transformation were generated by planned immunization of a blood donor volunteer with repeated HLA-immunizations over the course of 9 yr. Reactivity of 454A.C5 was in exact concordance with the presence of the DQw2 antigen as defined by microcytotoxicity assay on a panel of 21 B lymphoblastoid cell lines with well-characterized HLA antigens. Family studies showed the segregation according to the HLA-DQw2 haplotype; thus we demonstrate by serological and formal genetics criteria, that the alloantibody is specifically directed against the DQw2. 454A.C5 antibody may be employed as a monospecific HLA typing reagent.
Pistillo MP1, Sguerso V, Ferrara GB. High yields of anti-HLA human monoclonal antibodies can be provided by SCID mice. Hum Immunol. 1992 Dec;35(4):256-9 .In an attempt to develop a suitable model for increasing the yield of human anti-HLA mAbs, we have used mice with SCID for i.p. injection of two human-mouse heterohybridomas. HMP1 hybridoma secretes a DQB1*0201 allele-specific human mAb
Viken HD, Paulsen G, Sollid LM, Lundin KE, Tjønnfjord GE, Thorsby E, Gaudernack G. Characterization of an HLA-DQ2-specific monoclonal antibody. Influence of amino acid substitutions in DQ beta 1*0202. Hum Immunol. 1995 Apr;42(4):319-27. The HLA-DQ(alpha 1*0501, beta 1*0201) and-DQ(alpha 1*0501, beta 1*0202) (i.e., DQ2) heterodimers are probably involved in the pathogenesis of celiac disease and several other HLA-DQ-associated diseases. To obtain a tool for studies of these molecules, a mAb of the IgG1 isotype, 2.12.E11, was produced by immunization with purified DQ(alpha 1*0501, beta 1*0201) molecules and murine NIH 3T3 cells transfected with both DQA1*05011 and DQB1*0202. Panel cell studies with HLA homozygous B-lymphoblastoid cells and HLA-transfected murine cells demonstrated that 2.12.E11 bound only to cells expressing HLA-DQ beta 1*0201 or 0202, irrespective of the accompanying DQ alpha chain (i.e., DQ alpha 1*0501 or DQ alpha 1*0201). Another DQ2-specific mAb (XIII 358.4) and the broadly HLA class-II-reactive mAb Tü39 strongly inhibited binding of 2.12.E11. Epitope mapping employing mutants with single aa substitutions of DQ beta 1*0202 indicated that position 37 may be of some importance for 2.12.E11 binding. A triple mutant (45G-->E, 46E-->V, 47F-->Y) failed to bind 2.12.E11, suggesting a crucial role for one or more of these residues in the epitope. On the other hand, substitutions of residues unique to DQ2 such as 30S, 47F, 71K and 74A did not significantly affect the reactivy with these three DQ2specific antibodies.
Viken HD1, Paulsen G, Drover S, Marshall WH, Sollid LM, Gaudernack G, Thorsby E. Influence on antibody recognition of amino acid substitutions in the cleft of HLA-DQ2 molecules. Suggestive evidence of peptide-dependent epitopes. Hum Immunol. 1995 Oct;44(2):63-9. The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 genes encoding either wild-type or mutated DQ beta 1 *0202. Several aa substitutions were found to influence the binding of DQ2 mAbs. All but one of the mAbs were clearly sensitive to the introduced aa substitutions, but individual mAbs were differentially influenced, suggesting that they recognized different epitopes on the DQ2 molecule. Substitutions in positions 30 and 37 of the peptide-binding cleft were also found to influence the binding of some mAbs. Second, two mAbs, NFLD.M71 and NFLD.M102, which bound to DQ(alpha 1*0501, beta 1*0202) expressed in human cells and were sensitive to the introduction of aa substitutions in the cleft, bound weakly to the DQ(alpha 1*0501, beta 1*0202) heterodimer when expressed in a transfected murine NIH 3T3 cell line. Together this indicates that some DQ2-reactive mAbs may recognize peptide-dependent epitopes.
Common example of an antibody reacting only with DQ2:
Example of a serum reacting with DQ2 with additional antibodies specific for 47KHL unqiue on DQA1*02:
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DQB1*02:01, DQB1*02:02
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View (7)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07,
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443 |
52PQ
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53Q89G90I |
High |
View
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Yes
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52PQ on DQB1*05, *06
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Previously named 52PQ2, 52PQ has two separate configurations of unique polymorphic residues 53Q and 89G and 90I in opposite locations on the top of the DQB molecule.
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Note: Current lots of DQA-DQB panels supplied by the two major commercial vendors have only DQB1*05 and DQB1*06 dimers together with DQA1*01 alleles Their reactivity patterns cannot distinguish between antibodies specific for 52PQ2 and a DQA1 eplet. Certain previous SAB kits had dimers that were informative. One kit had the DQB1*03:02-DQA1*01:01 dimer and as shown below the immunizing DQB1*06:01-DQA1*01:03 induced antibodies specific for 52PQ2 because DQB1*03:02-DQA1*01:01 gave a negative reactive reaction.
Hansen T1, Kolstad A, Mathisen G, Hannestad K. “A human-human hybridoma (Tr7E2) producing cytotoxic antibody to HLA-DQw1”. Hum Immunol. 1987 Dec;20(4):307-20. A human-human IgM (lambda) hybridoma antibody (called Tr7E2) was constructed by fusing Epstein-Barr virus-transformed cells from a multiparous woman with the human fusion partner KR12. By eosin exclusion microcytotoxicity the monoclonal antibody killed 12 of 13 human leukocyte antigen DQw1-bearing lymphoblastoid cells. No reaction was seen with any of 19 DQw1-negative cells. The single DQw1+ cell line that was not killed by Tr7E2 was the homozygous cell called 9WS 806 TAB (DR8,8; DQw1,1) of Japanese origin. The radioimmunoassay indicated that this result was probably not because of a decreased expression by this cell of DQ antigens, and these cells were killed by the mouse monoclonal antibody Genox3.53G2a5, reported to be specific for DQw1. Thus, the Tr7E2- cell line TAB probably expresses a novel structural DQw1 variant. Of 213 Norwegians, 107 were Tr7E2+ Genox+; none expressed only one of these epitopes. The putative split is, therefore, probably very rare in this population. Monodisperse magnetic polymer beads coated with Tr7E2 formed rosettes selectively with peripheral blood mononuclear cells from DQw1-positive individuals, suggesting a new approach to typing for class II antigens.
Koning, F., J. Raghoebar, et al. (1985). "A monoclonal antibody detecting a DQw1-related determinant." Tissue Antigens 26: 100-106. Mouse mAb IIB3 reacts with DQw1.
Marsh, S. G. and J. G. Bodmer (1989). "HLA-DR and -DQ epitopes and monoclonal antibody specificity." Immunology Today 10: 305-312. Mouse mAb TAL4.1 (10W30920 reacts with postulated 53Q54G55R56P, 84E85V, 89G90I on DQ
Dessi, V., B. Sanchez, et al. (1990). "Characterization of three human monoclonal antibodies specific for polymorphic class I and class II HLA antigens." Human Immunology 27(4): 323-332. Three human mAb 34F11, RRA7 and RRF9 from a polytransfused patient who typed as A1,A9; B35, B37, DR3, DR4; DR52, DR53, DQ2, DQ3 were specific for DQ1 (DQ5+6) in FACS and CDC with B-LCL and with PBL
Navarrete et al, Genetic Diversity of HLA – Functional and Medical Implications, vol. 1, D. Charron (Ed), pp 11-17, 1997: Mouse mAbs TAL4.1 (12w577) and G2A5 (12w578) positive with HLA-DQB1*05:01, *05:02, *05:03, *06:01, *06:02, *06:03, *06:04 in CDC assays in 12th IHWS (r values range 0.81-0.84).
Nelson et al, Immunobiology of HLA, vol. I, B. Dupont (Ed), pp. 292-301, 1989: Monoclonal antibodies GENOX3.53 (10w3094), G2A5 (10w3095), GS148.1 (10w3096), 1.2 (10w3100) react with HLA-DQ1 on PBL and B-LCL in micro ELISA assays in 10th IHWS. All antibodies are weak with PBL.
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152.Absorption-elution studies on sera from three DRB1*05:01 or *05:02 or *06:03 mismatched transplant patients showed antibodies to a DQB epitope defined by 84E and corresponding to Terasaki’s epitope # 2004. (Editor’s note: 84E is part of the 52PQ2 eplet)
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DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (64)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:23, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
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445 |
55PP
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55P56P |
High |
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Yes
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55PP on DQB1*03:01/02/03
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Marsh, S. G. and J. G. Bodmer (1989). "HLA-DR and -DQ epitopes and monoclonal antibody specificity." Immunology Today 10: 305-312. MAbs HU18 (11W3111), PLM12 (10W3112) and GSP100.1 (10W3101) react with a postulated 53L54G55P56P epitope on DQw3
Nelson et al, Immunobiology of HLA, vol. I, B. Dupont (Ed), pp. 292-301, 1989: Mouse mAbs IVD12 (10w3108), HU18 (10w3111), GS100.1 (10w3114), 17.15 (10w3115), AC60 (10w3118) react with HLA-DQ3 on PBL and B-LCL in micro ELISA assays in 10th IHWS. IVD12, GS100.1, 17.15 and AC60 are weak with PBL.
Navarrete et al, Genetic Diversity of HLA – Functional Medical Implications vol. 1, D. Charron (Ed), pp 11-17, 1997: : Five mouse mAbs react with HLA-DQB1*03:01, *03:02, *03:03.
Viken HD1, Thoresen AB, Thorsby E, Hansen T. The cytotoxic HLA-DQ3 reactive human hybridoma antibody 4166 that may distinguish DQ7 + 8 from DQ9. Hum Immunol. 1995 Apr;42(4):281-8. The human cytotoxic hybridoma antibody 4166 (IgM kappa) was generated by fusing an in vitro EBV-transformed B-LCL from a multiparous woman with the mouse-human heteromyeloma fusion partner CB-F7. In microcytotoxicity and IIF tests with B-LCLs as target cells, the mAb 4166 was specific for DQ3 (= DQ7 + 8 + 9). However, when used for DQ typing of class-II-positive PBMCs, 4166 could be rendered functionally specific for DQ7 + 8 and did not react with DQ9+ PBMCs. Binding of mAb 4166 to DQ8-positive cells was efficiently blocked by several allotype-specific mAbs recognizing DQ8. Other HLA class-II-specific mAbs were unable to inhibit. With the use of mAb 4166, it is possible to discriminate DQ7 + 8 from DQ9 in serologic DQ typing.
Deng et al, Clinical Transplants 2006, pp 115-122 : Five mouse mAbs react with HLA-DQB1*03:01, *03:02, *03:03
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from three DQB1*03:02 or *03:03 mismatched transplant patients showed antibodies to a DQB epitope defined by 55P and corresponding to Terasaki’s epitope # 2006.
Antibodies specific for 55PP are very common
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DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19
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View (41)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44,
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446 |
55PPA
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55P56P57A |
High |
View
Click on a Luminex® HLA allele that shares the eplet 55PPA to view it at pHLA3D
DQB1*03:02,
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DQB1*03:02
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View (11)
List of Luminex® HLA alleles
DQB1*03:02,
List of all (Luminex® or not) HLA alleles
DQB1*03:02, DQB1*03:04, DQB1*03:05, DQB1*03:07, DQB1*03:08, DQB1*03:11, DQB1*03:14, DQB1*03:18, DQB1*03:32, DQB1*03:37, DQB1*06:29,
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447 |
55PPD
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55P56P57D |
High |
View
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DQB1*03:01, DQB1*03:03, DQB1*03:19
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View (31)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:03, DQB1*03:19,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:03, DQB1*03:06, DQB1*03:09, DQB1*03:10, DQB1*03:12, DQB1*03:13, DQB1*03:15, DQB1*03:17, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44,
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447 |
55R
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55R |
High |
View
Click on a Luminex® HLA allele that shares the eplet 55R to view it at pHLA3D
DQB1*04:01,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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Yes
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55R on DQB1*04, *05, *06
This eplet was previously named 52PR.
Kolstad, A., B. Johansen, et al. (1989). “Two HLA-DQ-specific human-human hybridoma antibodies (TrG6;TrC5) define epitopes also expressed by a transcomplementing hybrid DQ molecule (DQw7 alpha/DQw4 beta).” Human Immunology 24(1): 15-29. Human mAb TrG6 reacts with DQ1 and DQ4 expressing B-LCL. Residue 55R is important for the TrG6 specificity. We have generated two IgG human-human hybridoma Abs, TrG6 and TrC5, that define subsets of HLA-DQ. TrG6 combined selectively with lymphoblastoid cell lines that expressed DQw1 or DQw4. By sequential immunoprecipitation, competition with other mAbs of defined specificity for binding to antigen, and experiments where HLA antigens from cell lysates crosslinked pairs of mAbs, it was established that TrG6 bound a DQ-molecule. mAb TrC5 specifically recognized DQw2+DR3+ and DQw7+DR5+ cells. The reaction pattern of TrC5 with HLA-loss mutants indicated that TrC5 bound to DQw2 of the DQw2+DR3+ haplotype. Antigens in lysate from DQw7+DR5+ cells crosslinked TrC5 to the murine mAbs Tü22 (anti-DQ monomorphic) and IVD-12 (anti-DQw7 + DQw8 + DQw9), demonstrating that on these cells the TrC5 epitope is located on DQw7 molecules. Lysates from DQw7+DR5+/ DQw4+DRw8+ heterozygous cells crosslinked TrG6 and TrC5, and available evidence indicated that the epitopes defined by these two mAbs were expressed by the transcomplementing DQ-molecule DQw7 alpha/DQw4 beta, where the DQw7 alpha chain specifies epitope TrC5 and the DQw4 beta chain specifies epitope TrG6. Taken together with published nucleotide sequences of DQ alpha and beta genes, our data are consistent with the conclusion that the amino acids at positions 69 and/or 75 of the DQ alpha chain of DQw2+DR3+ and DQw7+DR5+ haplotypes are critical for epitope TrC5. The previously reported human-human hybridoma Ab TrB12 reacts with DQw6, DQw8, and DQw9. The specificity of the murine mAb IIB3 is similar to that of TrB12, but, unlike TrB12, IIB3 also binds DQw4+ cells.
Marsh, S. G. and J. G. Bodmer (1989). “HLA-DR and -DQ epitopes and monoclonal antibody specificity.” Immunology Today 10: 305-312. mAbs SH1 ((9W901), SH2 (9W927) and KS1 (10W3121) react with postulated 54G55R on DQw1, w4
Nelson et al, Immunobiology of HLA, vol. I, B. Dupont (Ed), pp. 292-301, 1989: Monoclonal antibody KS.11 (10w3091) positive with HLA-DQ1, DQ4 on peripheral blood lymphocytes and lymphoblastoid cell lines in micro ELISA assays in 10th IHWS.
Kennedy et al, Immunobiology of HLA, vol. I, B. Dupont (Ed), pp. 301-305, 1989: Monoclonal antibody KS.11 (10w3091) positive with HLA-DQ1, DQ4 peripheral blood lymphocytes and lymphoblastoid cell lines in CDC assays in 10th IHWS.
Vitale M1, Pistillo MP, Tazzari PL, Falco M, Sun PF, Mantero S, Ferrara GB. Production and characterization of murine monoclonal antibodies recognizing HLA-DQ polymorphisms obtained by immunizing mice with transfected L cells. Hum Immunol. 1992 Jun;34(2):126-34. Two polymorphic anti-HLA-DQB1 mAbs, TM 902 and TM 903, have been produced by immunizing F1 mice (Balb/C x C3H) with HLA-DQ-transfected mouse L cells. Cytotoxic analysis on a panel of HLA-typed cell lines has shown that TM 903 reacts with the DQB1*0501, *0502, and *0503, DQB1*0601, *0602, *0603, and *0604, and DQB1*0401 and *0402 alleles. The use of transfectants expressing HLA-DR/DQ heterodimers demonstrates that TM903 is specific for the DQ-beta chain. Comparison of the amino acid sequences of the DQ-beta chain suggests residues 54-55 (GR) in the formation of TM903 epitope.
Sánchez B, de la Calle O, Yélamos J, Aguilera I, Sánchez F, Dessi V, Siervo S, García-Lozano JR, Melero J, Magariño R, et al. A human monoclonal antibody reacting against HLA-DQ1-, DQ4-, and a subset of DQ7-bearing cells. Hum Immunol. 1993 Feb;36(2):81-90. Human mAb 2A2 recognizes an epitope present in the HLA-DQ1 + 4 specifications and also on several DQ7-positive cells. We have investigated the extra reactions of this monoclonal reagent on a wider panel of DQ1-, DQ4-negative/DQ7-positive B-cell lines. The results obtained support the existence of two subtypes of the HLA-DQ7 specificity on the basis of their reactivity with human mAb 2A2; the DQ7/2A2-positive variant has been found in 12 of 29 BCLs positive for the DR11 antigen, and in four of eight BCLs bearing DR4-DQ7 haplotypes. It has also been detected in the DR12-positive cells assayed and in several unusual DR/DQ7 combinations not commonly found in Caucasoid populations, including the DR13-DwHAG and DR14-Dw16 haplotypes. Results from competition binding assays between 2A2 and well-characterized murine anti-DQ polymorphic mAbs suggest that the epitope recognized by human mAb 2A2 on DQ1- or DQ4-bearing haplotypes is located on the DQ beta chains of such specificities, being amino acid residues 54-55, the potential binding site of antibody 2A2, whereas the binding site on DQ7 antigens cannot be explained on the basis of known amino acid sequences
Navarrete et al, Genetic Diversity of HLA – Functional and Medical Implications, vol. 1, D. Charron (Ed), pp 11-17, 1997: Mouse monoclonal antibodies AL/DQ61 (12w584) and 236-30 (12w585, IgM) positive with HLA-DQ4, DQB1*05:01, *05:02, *05:03, *06:01, *06:02, *06:03, *06:04 in CDC assays in 12th IHWS (r values range 0.85-0.87).
El-Awar, N., A. Nguyen, et al. (2013). “HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines.” Human Immunology 74: 1141-1152. Absorption-elution studies on sera from DQB1*03:03 or *05:01 or *06:02 mismatched transplant patients showed antibodies to a DQB epitope defined by 55R and corresponding to Terasaki’s epitope # 2007.
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Example of an SAB assay of a pregnancy serum provided by Stefan Schaub (Basel, Switzerland) with 55R-reactive DQB antibodies
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Certain 55R-specific antibodies exhibit two reactivity patterns (see below). The group of 55R-carrying DQ5 and DQ6 alleles with higher MFI values carry the 53Q and 56P residues. In contrast, the 53L and 56L carrying DQ4 alleles have significantly lower MFI values
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DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (74)
List of Luminex® HLA alleles
DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:23, DQB1*03:25, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:07, DQB1*04:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
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448 |
55RPD
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55R56P57D |
High |
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DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03
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View (38)
List of Luminex® HLA alleles
DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03,
List of all (Luminex® or not) HLA alleles
DQB1*03:23, DQB1*05:03, DQB1*05:06, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:13, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:07, DQB1*06:11, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:19, DQB1*06:20, DQB1*06:23, DQB1*06:24, DQB1*06:28, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:35, DQB1*06:37, DQB1*06:40, DQB1*06:41, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50,
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449 |
56L
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56L71D |
High |
View
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Yes
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56L on DQB1*04
This eplet was previously named 55RL3.
Ishikawa, N., H. Kojima, et al. (1987). "Detection of a novel HLA-DQ specificity: serological and immunochemical analyses by a monoclonal antibody." Immunogenetics26(3): 143-149. A mouse mAb HU-46, reacted with B cells from not only DR4/Dw15-positive individuals but also certain DRw8/Dw8-positive ones whose DQ phenotypes had not yet been defined. Two-dimensional gel analyses indicated that the mAb recognized class II HLA-DQ encoded antigens. Furthermore, in genetic analysis, the gene encoding the class II antigen detected by HU-46 met the Hardy-Weinberg condition as a fourth allele of the DQ locus. The novel DQWa specificity is now called DQ4.
Matsuki K, Juji T, Satake M. A novel HLA class II alloantigen detected by an alloantiserum TK2. Hum Immunol. 1987 Mar;18(3):247-56. An alloantiserum, TK2, obtained from a kidney transplant patient, was investigated. TK2 reacted with B lymphocytes that had only one detectable DQ antigen. DQ "blank" homozygous cell lines were positive for TK2, but DQwl, DQw2, and DQw3 homozygous cell lines failed to react with TK2. Positive reactions for TK2 segregated with DQ "blank" haplotypes in the families studied. The reactivity of TK2 to B lymphocytes was strong, while its reactivity to monocytes was very weak. When TK2 was absorbed with DQ "blank" cells, it became unreactive to other lymphocytes. TK2 blocked the binding of an anti-DQ monoclonal antibody to DQ "blank" cells. It did not affect the binding of the antibody to DQw1 and DQw3 cells, nor did it affect the binding of an anti-DR monoclonal antibody to a DQ "blank" cell line. These findings suggest that TK2 can detect a new HLA class II alloantigen that corresponds to a DQ "blank" specificity.
Marsh, S. G. and J. G. Bodmer (1989). "HLA-DR and -DQ epitopes and monoclonal antibody specificity." Immunology Today 10: 305-312. MAb HU46 (11W3101) reacts with a postulated 53L54G55R56L,70A71D72R73A74S75V76D epitope on DQw4 epitope
Kennedy et al, Immunobiology of HLA, vol. I, B. Dupont (Ed), pp. 301-305, 1989: Mouse mAb HU46 (10w3101) reacts with HLA-DQ4 on PBL and B-LCL in CDC assays in 10th IHWS.
Navarrete et al, Genetic Diversity of HLA – Functional and Medical Implications, vol. 1, D. Charron (Ed), pp 11-17, 1997: Mouse mAbHU-46 (12w609) positive with HLA-DQ4 in CDC assays in 12th IHWS (r=0.48), with unexplained false positive reactions.
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DQB1*04:01, DQB1*04:02
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View (9)
List of Luminex® HLA alleles
DQB1*04:01, DQB1*04:02,
List of all (Luminex® or not) HLA alleles
DQB1*03:25, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08,
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450 |
56P
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56P |
High |
View
Click on a Luminex® HLA allele that shares the eplet 56P to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (116)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
|
|
451 |
56PA
|
56P57A |
High |
View
|
|
|
|
DQB1*02:01, DQB1*02:02, DQB1*03:02
|
View (17)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:02,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:02, DQB1*03:04, DQB1*03:05, DQB1*03:07, DQB1*03:08, DQB1*03:11, DQB1*03:14, DQB1*03:18, DQB1*03:32, DQB1*03:37, DQB1*06:29,
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452 |
56PD
|
56P57D |
High |
View
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DQB1*03:01, DQB1*03:03, DQB1*03:19, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03
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View (71)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:03, DQB1*03:19, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03,
List of all (Luminex® or not) HLA alleles
DQB1*02:03, DQB1*03:01, DQB1*03:03, DQB1*03:06, DQB1*03:09, DQB1*03:10, DQB1*03:12, DQB1*03:13, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*05:03, DQB1*05:06, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:13, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:07, DQB1*06:11, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:19, DQB1*06:20, DQB1*06:23, DQB1*06:24, DQB1*06:28, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:35, DQB1*06:37, DQB1*06:40, DQB1*06:41, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50,
|
|
452 |
56PS
|
56P57S |
High |
View
Click on a Luminex® HLA allele that shares the eplet 56PS to view it at pHLA3D
DQB1*05:02,
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DQB1*05:02
|
View (6)
List of Luminex® HLA alleles
DQB1*05:02,
List of all (Luminex® or not) HLA alleles
DQB1*05:02, DQB1*05:04, DQB1*05:05, DQB1*05:14, DQB1*06:10, DQB1*06:25,
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|
453 |
57V
|
57V |
High |
View
|
Yes
|
57V on DQB1*05:01, DQB1*06:04 and DQB1*06:09
This eplet was previously named 56PV.
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on serum 31 from a DQB1*05:01 mismatched transplant patient who typed as DQB1*03:01, DQB1*06:02 showed antibodies that reacted only with DQB1*05:01 but not DQB1*05:02 . This eluate seems to recognize an epitope defined referred to as Terasaki’s epitope #2022.
Pregnancy serum from Stefan Schaub (Basel, Switzerland) It reacts also weakly with DQB alleles that carry the unverified 70RT eplet defined by 70R and 71T
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DQB1*05:01, DQB1*06:04, DQB1*06:09
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View (22)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*05:01, DQB1*05:07, DQB1*05:11, DQB1*05:12, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:08, DQB1*06:09, DQB1*06:12, DQB1*06:13, DQB1*06:17, DQB1*06:18, DQB1*06:21, DQB1*06:22, DQB1*06:27, DQB1*06:34, DQB1*06:36, DQB1*06:38, DQB1*06:39, DQB1*06:42, DQB1*06:52,
|
|
454 |
66D
|
66D67I |
High |
View
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|
|
DQB1*02:01, DQB1*02:02, DQB1*04:01, DQB1*04:02, DQB1*06:01
|
View (22)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*04:01, DQB1*04:02, DQB1*06:01,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:06, DQB1*03:25, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:04, DQB1*06:01, DQB1*06:35, DQB1*06:43, DQB1*06:45,
|
|
455 |
66DR
|
66D67I70R |
High |
View
|
|
|
|
DQB1*02:01, DQB1*02:02, DQB1*06:01
|
View (11)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*06:01,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*06:01, DQB1*06:35, DQB1*06:43, DQB1*06:45,
|
|
456 |
66ER
|
66E67V70R71T |
High |
View
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|
|
|
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*06:04, DQB1*06:09
|
View (58)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:07, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:09, DQB1*06:15, DQB1*06:18, DQB1*06:22, DQB1*06:25, DQB1*06:27, DQB1*06:32, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:48, DQB1*06:52,
|
|
457 |
66EV
|
66E67V |
High |
View
Click on a Luminex® HLA allele that shares the eplet 66EV to view it at pHLA3D
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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|
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (102)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
|
|
458 |
67VG
|
66E67V70G |
High |
View
|
|
|
|
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:02, DQB1*06:03
|
View (44)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:02, DQB1*06:03,
List of all (Luminex® or not) HLA alleles
DQB1*03:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:02, DQB1*06:03, DQB1*06:08, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:17, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:23, DQB1*06:24, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:33, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:49, DQB1*06:50,
|
|
459 |
67VT
|
67V71T |
High |
View
|
|
|
|
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (83)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
|
|
460 |
70GT
|
67V70G71T |
High |
View
|
|
|
|
DQB1*06:02, DQB1*06:03
|
View (25)
List of Luminex® HLA alleles
DQB1*06:02, DQB1*06:03,
List of all (Luminex® or not) HLA alleles
DQB1*03:08, DQB1*06:02, DQB1*06:03, DQB1*06:08, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:23, DQB1*06:28, DQB1*06:29, DQB1*06:31, DQB1*06:33, DQB1*06:40, DQB1*06:41, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:49, DQB1*06:50,
|
|
461 |
70RT
|
70R71T |
High |
View
|
|
|
|
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*06:01, DQB1*06:04, DQB1*06:09
|
View (63)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*06:01, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:07, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*06:01, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:09, DQB1*06:15, DQB1*06:18, DQB1*06:22, DQB1*06:25, DQB1*06:27, DQB1*06:32, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:43, DQB1*06:45, DQB1*06:48, DQB1*06:52,
|
|
462 |
74EL
|
74E75L77T |
High |
View
|
|
|
|
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
|
View (90)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:26, DQB1*03:27, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
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464 |
74S
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74S26G |
High |
View
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Yes
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74S on DQB1*04 and DQB1*05
This eplet was previously named 74SV2.
Ge, J. and K. Hannestad (1994). "A cytotoxic human hybridoma monoclonal antibody (TrJ6) defining an epitope expressed by HLA-DQ4 and -DQ5." Human Immunology 39(2): 106-112. Pregnancy-induced human mAb TrJ6 reacts with DQ4 and DQ5 in CDC and flow cytometry assays. They share 74S and 75V. The specific binding of TrJ6 to a DQ4-bearing line was efficiently blocked by IIB3 (murine anti-DQ8+9+4+5+6 mAb) and TrG6 (human IgG mAb against DQ4+5+6), confirming that TrJ6 is specific for a polymorphic DQ epitopeReactivity was stronger with DQ4 than DQ5 suggesting that DQ4 residues 56L, 70E and 71D and 77R make a minor contribution to this epitope.
Duquesnoy, R., Y. Awadalla, et al. (2008). "Retransplant Candidates Have Donor-Specific Antibodies that React with Structurally Defined HLA-DR,DQ,DP Epitopes." Transplant Immunology. 18: 352-360. Some transplant patients have donor-specific 74SV-related antibodies
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DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03
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View (26)
List of Luminex® HLA alleles
DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03,
List of all (Luminex® or not) HLA alleles
DQB1*03:06, DQB1*03:25, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16,
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465 |
75V
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75V |
High |
View
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DQB1*02:01, DQB1*02:02, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03
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View (34)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:06, DQB1*03:25, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:06,
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466 |
77R
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75V77R |
High |
View
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Yes
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77R on DQB1*02 and DQB1*05
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152.Absorption-elution studies on sera from two transplant patients who typed as DQB1*03:02 (mismatch: DQB1*05:02) and DQB1*03:02,DQB1*06:04 (mismatch: DQB1*02:02)and had antibodies to a DQB epitope defined by 77R and corresponding to Terasaki’s epitope # 2026.
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DQB1*02:01, DQB1*02:02, DQB1*05:01, DQB1*05:02, DQB1*05:03
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View (23)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*05:01, DQB1*05:02, DQB1*05:03,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:06, DQB1*02:07, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:06,
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467 |
77T
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77T |
High |
View
Click on a Luminex® HLA allele that shares the eplet 77T to view it at pHLA3D
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*04:01,
DQB1*04:02,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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Yes
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77T on DQB1*03, DQB1*04 and DQB1*06
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from a DQB1*03:01/02 mismatched transplant patient who typed as DQB1*02:02,DQB1*05:02 and had antibodies to a DQB epitope defined by 77T and corresponding to Terasaki’s epitope # 2027.
This DQB1*06:02-induced antibody reacted with all 77T-carrying DQB alleles although DQ4 alleles showed much lower MFI values. The differences in reactivity could be explained by residue differences in nearby positions 74 and 75.
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DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (101)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:05, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*03:27, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:40, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50, DQB1*06:52,
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468 |
84QL
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84Q86E87L89T... |
High |
View
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Yes
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84QL on DQB1*02, DQB1*03, and DQB1*04
This eplet was previously named 84QL3.
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84QL represents two separate configurations in opposite locations on the top of the DQB molecule: 84Q85L86EL87L89T90T (see left figure; 86E and 90T are not visible) and 53L (see right figure). The 125A residue is unique on DQ2,DQ3,DQ4 and is located in the membrane proximal domain.
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Vitale, M., M. P. Pistillo, et al. (1992). "Production and characterization of murine monoclonal antibodies recognizing HLA-DQ polymorphisms obtained by immunizing mice with transfected L cells." Human Immunology. 34(2): 126-134. Mouse mAb TM 902 reacted in cytotoxicity assays with B-LCL and by flow cytometry with all DQB1* alleles except DQB1*0501, *0502, *0503, and DQB1*0601, *0602, *0603, *0604. Comparison of the amino acid sequences of the DQB chain suggests the involvement of residues 84-90 (QLELRTT) in the formation of TM902 epitope.
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from two DQB1*02:02 or *03:19 mismatched transplant patients showed antibodies to a DQB epitope defined by 84Q and corresponding to Terasaki’s epitope # 2013.
Radka SF, Stewart SJ, Smith SA. Analysis of HLA-DQ molecules with a monoclonal antibody detecting a DQ polymorphism absent from DQW1 homozygous cells. Hum Immunol. 1985 Nov;14(3):206-19. We have produced a monoclonal antibody detecting an HLA class II determinant absent from DR1,2,W6, and W10 (DQW1) homozygous B lymphoblastoid cell lines (BLCL). The antibody, SFR16-PI.2, immunoprecipitates molecules with electrophoretic mobilities of DQ (DS/DC) molecules from DR7 homozygous cell lines. SFR16-PI.2 binds more sets of class II molecules from internally labeled DR7 homozygous cell membranes than from externally labeled extracts from the same cell line. Depletion of DR molecules from internally-labeled membranes indicates that SFR16-PI.2, in addition to reacting with DQ molecules, also reacts with an epitope on a biosynthetic intermediate of DR molecules, which is lost on the mature DR molecule. SFR16-PI.2-reactive molecules were examined on a DR5 homozygous cell line, where they could be compared to those isolated by two other monoclonal antibodies with DQ specificity, namely IVD12 and Leu-10. All three monoclonal antibodies isolated two sets of DQ molecules with varying degrees of affinity for one of the molecules. The serological and biochemical data presented suggest that SFR16-PI.2 detects the alternate alleles of the locus encoding DQW1.
Deng et al, Transplantation 86: 452-459, 2008 :Two post renal transplant allosera positive with DQB1*02:01, *02:02, *03:01, *03:02, *03:03, *04:01, *04:02. One serum (case 9) came from an Ab producer who typed as HLA-DQ5, 6; donor typed as HLA-DQ4,5. Alloserum 16975 and eluate (absorbed with DQ7 cells) show same reactivity pattern.
 
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DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02
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View (59)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*02:06, DQB1*02:07, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:37, DQB1*03:38, DQB1*03:39, DQB1*03:40, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:04, DQB1*04:05, DQB1*04:06, DQB1*04:07, DQB1*04:08,
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469 |
86A
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86A |
Intermediate |
View
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DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03
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View (48)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03,
List of all (Luminex® or not) HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:08, DQB1*06:10, DQB1*06:11, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:23, DQB1*06:24, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:35, DQB1*06:37, DQB1*06:40, DQB1*06:41, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50,
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472 |
87F
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87F |
High |
View
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Yes
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87F on DQB1*06:01, DQB1*06:02 and DQB1*06:03
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DQB1*06:01, DQB1*06:02, DQB1*06:03
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View (32)
List of Luminex® HLA alleles
DQB1*06:01, DQB1*06:02, DQB1*06:03,
List of all (Luminex® or not) HLA alleles
DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:08, DQB1*06:10, DQB1*06:11, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:23, DQB1*06:24, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:35, DQB1*06:37, DQB1*06:40, DQB1*06:41, DQB1*06:43, DQB1*06:44, DQB1*06:45, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:50,
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472 |
87Y
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87Y |
Intermediate |
View
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Yes
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87Y on DQB1*05, DQB1*06:04 and DQB1*06:09
This eplet was previously named 85VY.
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DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:04, DQB1*06:09
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View (33)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:06, DQB1*05:07, DQB1*05:08, DQB1*05:09, DQB1*05:10, DQB1*05:11, DQB1*05:12, DQB1*05:13, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:09, DQB1*06:12, DQB1*06:15, DQB1*06:17, DQB1*06:21, DQB1*06:22, DQB1*06:25, DQB1*06:34, DQB1*06:36, DQB1*06:38, DQB1*06:39, DQB1*06:42, DQB1*06:46, DQB1*06:52,
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473 |
116I
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116I125S |
High |
View
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Yes
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116I on DQB1*05
This eplet was previously named 74SR3.
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116I on DQB1*05:01/02 has three unique residues: 71A (on the top) and 116I and 125S in the membrane-proximal domain.
Residue 14L is also unique but it is hidden and not antibody-accessible
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Marsh, S. G. and J. G. Bodmer (1989). "HLA-DR and -DQ epitopes and monoclonal antibody specificity." Immunology Today 10: 305-312. Mouse mAb HU-33 (9W924) reacts with a postulated 71A72R73A74S75V76D77R epitope on DQw5.
Deng et al, Clinical Transplants 2006, pp 115-122 : Post renal transplant alloserum 04-08446 reacted with HLA-DQB1*05:01, *05:02 (Ab producer types as HLA-DQ6; donor DQ5,2).
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152 Serum (#30) from a DQB1*05:01 mismatched transplant patient who typed as DQB1*02:01, DQB1*06:09 and showed antibodies to a DQB epitope defined by 125S and corresponding to Terasaki’s epitope #2015. DQB1*05:01 and DQB1*05:02 share the 125S-defined epitope but they also share a unique 71A and 116I.
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DQB1*05:01, DQB1*05:02, DQB1*05:03
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View (13)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*05:02, DQB1*05:03,
List of all (Luminex® or not) HLA alleles
DQB1*03:31, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*05:07, DQB1*05:08, DQB1*05:10, DQB1*05:12, DQB1*05:14, DQB1*05:15, DQB1*05:16,
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473 |
125G
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125G |
Very Low |
View
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DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (31)
List of Luminex® HLA alleles
DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:20, DQB1*06:21, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:52,
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474 |
125SQ
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125S126Q |
Low |
View
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Yes
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125SQ on DQB1*05:01
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines."Human Immunology 74: 1141-1152. Absorption-elution studies on serum 31 from a DQB1*05:01 mismatched transplant patient who typed as DQB1*03:01, DQB1*06:02 showed antibodies that reacted only with DQB1*05:01 (which has 125S+126Q) but not DQB1*05:02 (which has 125S+126H). This eluate seems to recognize an epitope defined by 125SQ and which is referred to as Terasaki’s epitope #2022. No information was provided about the reactivity with DQB1*05:03 which has 125SQ, or other informative DQB1*05 alleles.
El-Awar N, Jucaud V, Nguyen A (2017). HLA epitopes: The targets of monoclonal and alloantibodies defined. Journal of Immunology Research vol. 2017, article ID 3406230 (http://doi.org/10.1155/2017/3406230).
Unadsorbed alloserum reacts with the 125SQ and 57V carrying DQB1*05:01 only but not DQB1*05:02, which has 125SH and 57S.
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DQB1*05:01, DQB1*05:03
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View (8)
List of Luminex® HLA alleles
DQB1*05:01, DQB1*05:03,
List of all (Luminex® or not) HLA alleles
DQB1*05:01, DQB1*05:03, DQB1*05:07, DQB1*05:08, DQB1*05:10, DQB1*05:12, DQB1*05:15, DQB1*05:16,
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474 |
130Q
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86G130Q |
Intermediate |
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DQB1*06:04, DQB1*06:09
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View (13)
List of Luminex® HLA alleles
DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*03:22, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:09, DQB1*06:12, DQB1*06:21, DQB1*06:34, DQB1*06:36, DQB1*06:38, DQB1*06:41, DQB1*06:42, DQB1*06:52,
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475 |
130R
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130R |
High |
View
Click on a Luminex® HLA allele that shares the eplet 130R to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*04:01,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
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DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03
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View (72)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:06, DQB1*02:07, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:12, DQB1*03:13, DQB1*03:16, DQB1*03:19, DQB1*03:21, DQB1*03:24, DQB1*03:25, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:38, DQB1*03:39, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:01, DQB1*04:02, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:07, DQB1*05:08, DQB1*05:10, DQB1*05:12, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:08, DQB1*06:10, DQB1*06:11, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:20, DQB1*06:33, DQB1*06:37, DQB1*06:39, DQB1*06:43, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49,
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476 |
135D
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135D |
High |
View
Click on a Luminex® HLA allele that shares the eplet 135D to view it at pHLA3D
DQB1*02:01,
DQB1*03:01,
DQB1*03:02,
DQB1*03:03,
DQB1*03:19,
DQB1*04:01,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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DQB1*02:01, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (82)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:04, DQB1*02:07, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:12, DQB1*03:13, DQB1*03:16, DQB1*03:19, DQB1*03:21, DQB1*03:22, DQB1*03:24, DQB1*03:25, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:35, DQB1*03:36, DQB1*03:38, DQB1*03:39, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:01, DQB1*04:02, DQB1*04:06, DQB1*04:07, DQB1*04:08, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:07, DQB1*05:08, DQB1*05:10, DQB1*05:12, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:20, DQB1*06:21, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:52,
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477 |
135G
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135G |
High |
View
Click on a Luminex® HLA allele that shares the eplet 135G to view it at pHLA3D
DQB1*02:02,
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DQB1*02:02
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View (2)
List of Luminex® HLA alleles
DQB1*02:02,
List of all (Luminex® or not) HLA alleles
DQB1*02:02, DQB1*02:06,
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479 |
167H
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167H |
High |
View
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DQB1*03:01, DQB1*03:19, DQB1*06:01
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View (21)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:19, DQB1*06:01,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:04, DQB1*03:09, DQB1*03:10, DQB1*03:13, DQB1*03:16, DQB1*03:19, DQB1*03:21, DQB1*03:22, DQB1*03:24, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:35, DQB1*03:36, DQB1*03:42, DQB1*03:44, DQB1*04:08, DQB1*05:08, DQB1*06:01, DQB1*06:43,
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480 |
167R
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167R |
High |
View
Click on a Luminex® HLA allele that shares the eplet 167R to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:02,
DQB1*03:03,
DQB1*04:01,
DQB1*04:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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DQB1*02:01, DQB1*02:02, DQB1*03:02, DQB1*03:03, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (62)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:02, DQB1*03:03, DQB1*04:01, DQB1*04:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:04, DQB1*02:06, DQB1*02:07, DQB1*03:02, DQB1*03:03, DQB1*03:05, DQB1*03:08, DQB1*03:25, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:33, DQB1*03:34, DQB1*03:38, DQB1*03:39, DQB1*03:41, DQB1*03:43, DQB1*04:01, DQB1*04:02, DQB1*04:06, DQB1*04:07, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:07, DQB1*05:10, DQB1*05:12, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:20, DQB1*06:21, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:41, DQB1*06:42, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:52,
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480 |
182N
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182N |
High |
View
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Yes
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182N on DQB1*03 and DQB1*04
This eplet was previously named 52PL3.
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DQB1*03:01/02/03 and DQB1*04:01/02 share two unique polymorphic residues, 140T and 182N on the membrane-proximal domain of the DQB chain. This eplet was originally described as 52PL3 but this notation has been changed to 182N since neither 52P or 53L is uniquely shared between DQ3 and DQ4.
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Navarrete et al, Genetic Diversity of HLA – Functional and Medical Implications, vol. 1, D. Charron (Ed), pp 11-17, 1997: Mouse mAb 178-38 (12w605) and TAL12.1 (12w606) react with HLA-DQB1*03:01, *03:02, *03:03 and DQ4 in CDC assays in 12th IHWS (r values range 0.74-0.85)
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from three DRB1*0301 or *03:02 or *03:03 mismatched transplant patients and showed antibodies to a DQB epitope defined by 182N and corresponding to Terasaki’s epitope # 2014. (Editor’s note: The 182N residue is in the 52PL3eplet)
Deng et al, Transplantation 86: 452-459, 2008: Serum 338 eluate (absorbed with DQ4 cells) positive with DQ4, 7, 8, 9
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DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02
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View (34)
List of Luminex® HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02,
List of all (Luminex® or not) HLA alleles
DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:13, DQB1*03:16, DQB1*03:19, DQB1*03:21, DQB1*03:22, DQB1*03:24, DQB1*03:25, DQB1*03:27, DQB1*03:28, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:35, DQB1*03:36, DQB1*03:38, DQB1*03:39, DQB1*03:41, DQB1*03:42, DQB1*03:43, DQB1*03:44, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*04:06, DQB1*04:07, DQB1*04:08,
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480 |
182S
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182S |
High |
View
Click on a Luminex® HLA allele that shares the eplet 182S to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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Yes
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182S on DQB1*02, *05,*06
This eplet was previously named 140A2.
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152.Absorption-elution studies on sera from a DQB1*05:02 mismatched transplant patient who typed as DQB1*03:02,- showed antibodies to an epitope DQB defined by 140A and corresponding to Terasaki’s epitope # 2023.
______________________________________________________________________________________________
182S pair
182S + 130R + 135D
L Daniëls; M-PEmonds; J-L Bosmans; M Marrari; RJ Duquesnoy Epitope analysis of DQ6-reactive antibodies in sera from a DQ6- positive transplant sensitized during pregnancy Transpl Immunol 2016 Sep;38:15-8
This case report describes DQ6-reactive serum antibody reactivity in a patient who types as DQ6. DNA typing showed DQB1*06:09 on the antibody producer and serum reactivity with DQB1*06:01, *06:02 and *06:03 but not with *06:04 and *06:09. Additionally, the serum reacted with DQB1*02:01 but not DQB1*02:02. After applying the nonself-self algorithm of HLA immunogenicity we have identified a new DQB epitope structurally described as 140A2+130R+135D, shared by DQB1*02:01 as well as DQB1*05:01 and DQB1*06:02 of the immunizer.
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DQB1*02:01, DQB1*02:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (46)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:04, DQB1*02:06, DQB1*02:07, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:07, DQB1*05:08, DQB1*05:12, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:20, DQB1*06:21, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:52,
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481 |
185I
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185I |
High |
View
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DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02
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View (18)
List of Luminex® HLA alleles
DQB1*03:02, DQB1*03:03, DQB1*03:19, DQB1*04:01, DQB1*04:02,
List of all (Luminex® or not) HLA alleles
DQB1*03:02, DQB1*03:03, DQB1*03:05, DQB1*03:08, DQB1*03:19, DQB1*03:25, DQB1*03:30, DQB1*03:31, DQB1*03:32, DQB1*03:38, DQB1*03:39, DQB1*03:41, DQB1*03:43, DQB1*04:01, DQB1*04:02, DQB1*04:06, DQB1*04:07, DQB1*04:08,
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482 |
185T
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185T |
High |
View
Click on a Luminex® HLA allele that shares the eplet 185T to view it at pHLA3D
DQB1*02:01,
DQB1*02:02,
DQB1*03:01,
DQB1*05:01,
DQB1*05:02,
DQB1*05:03,
DQB1*06:01,
DQB1*06:02,
DQB1*06:03,
DQB1*06:04,
DQB1*06:09,
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DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09
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View (64)
List of Luminex® HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*03:01, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:09,
List of all (Luminex® or not) HLA alleles
DQB1*02:01, DQB1*02:02, DQB1*02:04, DQB1*02:06, DQB1*02:07, DQB1*03:01, DQB1*03:04, DQB1*03:09, DQB1*03:10, DQB1*03:12, DQB1*03:13, DQB1*03:16, DQB1*03:21, DQB1*03:22, DQB1*03:24, DQB1*03:27, DQB1*03:28, DQB1*03:29, DQB1*03:35, DQB1*03:36, DQB1*03:42, DQB1*03:44, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:07, DQB1*05:08, DQB1*05:10, DQB1*05:12, DQB1*05:14, DQB1*05:15, DQB1*05:16, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:16, DQB1*06:20, DQB1*06:21, DQB1*06:33, DQB1*06:34, DQB1*06:36, DQB1*06:37, DQB1*06:38, DQB1*06:39, DQB1*06:41, DQB1*06:42, DQB1*06:43, DQB1*06:44, DQB1*06:46, DQB1*06:47, DQB1*06:48, DQB1*06:49, DQB1*06:52,
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426 |
2D
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2D199A |
Intermediate |
View
Click on a Luminex® HLA allele that shares the eplet 2D to view it at pHLA3D
DQA1*01:01,
DQA1*01:02,
DQA1*01:03,
DQA1*02:01,
DQA1*03:01,
DQA1*03:02,
DQA1*03:03,
DQA1*04:01,
DQA1*05:01,
DQA1*05:03,
DQA1*05:05,
DQA1*06:01,
|
Yes
2D on all DQA1 alleles except DQA1*01:04 and DQA1*01:05
Youngs D, Warner P, Gallagher M and Gimferrer I. New DQA1 allele specific antibody against epitope 2D (an exon 1 encoded amino acid). Considerations for alleles under the same P group designation. Transplant Immunology: 51, 32-39, 2018.
This is a case of a kidney recipient, typed as DQA1*01:04, 01:05 and DQB1*05:01P, 05:03, who developed antibodies against all DQ antigens on our Luminex Single Antigen (LSA) panel. Our LSA panel does not include DQA1*01:05 or 01:04, but both alleles belong to the DQA1*01:01P group and beads carrying DQA1*01:01 tested positive. Mature protein sequence alignment demonstrated a single AA mismatch between DQA1*01:04/01:05 and DQA1*01:01 located at position 2 (G vs D), which is encoded by exon 1. Luminex assay by another manufacturer which include a bead carrying patient's own DQA1* type and crossmatch studies with surrogate donors confirmed the presence of an antibody against mismatched epitope 2D. This case illustrates that alleles included in the same P-group may have polymorphisms able to trigger immunological responses and brings attention to the fact that some mature HLA proteins express AA encoded by exon 1, which is structurally part of the PBD.
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DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01
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View (18)
List of Luminex® HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*05:11, DQA1*06:01,
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427 |
2G
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2G199T |
Intermediate |
View
Click on a Luminex® HLA allele that shares the eplet 2G to view it at pHLA3D
DQA1*01:04,
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DQA1*01:04
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View (3)
List of Luminex® HLA alleles
DQA1*01:04,
List of all (Luminex® or not) HLA alleles
DQA1*01:04, DQA1*01:05, DQA1*01:07,
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428 |
25FT
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25F26T |
Very Low |
View
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DQA1*01:03, DQA1*02:01, DQA1*06:01
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View (4)
List of Luminex® HLA alleles
DQA1*01:03, DQA1*02:01, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*01:03, DQA1*02:01, DQA1*06:01, DQA1*06:02,
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429 |
25YT
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25Y26T |
Very Low |
View
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DQA1*01:01, DQA1*01:02, DQA1*01:04, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05
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View (22)
List of Luminex® HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:04, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05,
List of all (Luminex® or not) HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07, DQA1*01:08, DQA1*01:09, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*05:10, DQA1*05:11,
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429 |
40E
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40E |
High |
View
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Yes
40E on DQA1*01, *02, *03
This serum has also antibodies reacting with the DQB eplet 45GV.
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DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03
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View (13)
List of Luminex® HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03,
List of all (Luminex® or not) HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07, DQA1*01:08, DQA1*01:09, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03,
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430 |
40ERV
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40E41R45V |
High |
View
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DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03
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View (4)
List of Luminex® HLA alleles
DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03,
List of all (Luminex® or not) HLA alleles
DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03,
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431 |
40GR
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40G47C50V51L |
High |
View
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Yes
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40GR on DQA1*04, 05, 06
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Previously called 40GR3, 40GR may represent two distinct eplets defined by 40G, 47C, 50V and 51L; their locations are depicted in the molecular model.
52Q is part of an interlocus class II eplet.
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El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from four transplant patients with mismatches for DQA1*05 or *06 showed antibodies to a DQA epitope defined by 40G and corresponding to Terasaki’s epitope # 2018.
Deng, C. T., N. El-Awar, et al. (2008). "Human leukocyte antigen class II DQ alpha and beta epitopes identified from sera of kidney allograft recipients." Transplantation 86(3): 452-459. Post renal transplant alloserum 8702 and eluate (absorbed with DQA1*04:01 cells) reacts with HLA-DQA1*04:01, *05:01, *05:05, *06:01.
Tambur, A., J. R. Leventhal, et al. (2010). "The Complexity of Human Leukocyte Antigen (HLA)-DQ Antibodies and Its Effect on Virtual Crossmatching." Transplantation 90: 1117-1124. Luminex data illustrates antibody specificity for the 40GR-defined epitope.
Duquesnoy, R., Y. Awadalla, et al. (2008). "Retransplant Candidates Have Donor-Specific Antibodies that React with Structurally Defined HLA-DR,DQ,DP Epitopes." Transplant Immunology. 18: 352-360. In transplant patients, many DQA-reactive antibodies recognize 40GR.
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DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01
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View (16)
List of Luminex® HLA alleles
DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*05:10, DQA1*05:11, DQA1*06:01, DQA1*06:02,
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434 |
47KHL
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47K52H54L |
High |
View
Click on a Luminex® HLA allele that shares the eplet 47KHL to view it at pHLA3D
DQA1*02:01,
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Yes
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47KHL on DQA1*02
El-Awar, N., A. Nguyen, et al. (2013). "HLA class II DQA and DQB epitopes: Recognition of the likely binding sites of HLA-DQ alloantibodies eluted from recombinant HLA-DQ single antigen cell lines." Human Immunology 74: 1141-1152. Absorption-elution studies on sera from four transplant patients with DQA1*02:01 mismatches showed antibodies to an epitope DQB defined by 52H and corresponding to Terasaki’s epitope # 2017.
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DQA1*02:01 has three unique residues
47K (ElliPro score 0.201), 52H (0.740) and 54L (0.602) in close proximity.
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Deng, C. T., N. El-Awar, et al. (2008). "Human leukocyte antigen class II DQ alpha and beta epitopes identified from sera of kidney allograft recipients." Transplantation 86(3): 452-459.
Post renal transplant alloserum reactivity in Luminex
.jpg)
Duquesnoy, R., Y. Awadalla, et al. (2008). "Retransplant Candidates Have Donor-Specific Antibodies that React with Structurally Defined HLA-DR,DQ,DP Epitopes." Transplant Immunology. 18: 352-360.
Clinical examples
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DQA1*02:01
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View (1)
List of Luminex® HLA alleles
DQA1*02:01,
List of all (Luminex® or not) HLA alleles
DQA1*02:01,
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436 |
52SK
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52S53K11C18F... |
High |
View
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Yes
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52SK on DQA1*01
This eplet has been previously named 52SK5. 52SK has at least five distinct eplets, the ElliPro scores of their polymorphic residues are shown below:
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It should be noted that most SAB panels cannot distinguish antibodies specific because in such kits have DQB1*05 and DQB1*06 dimers that have only DQA1*01 but no other DQA1 alleles; moreover, there might be no DQ dimers whereby DQA1*01 is complexed with other DQB alleles.
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Chersi A, Romano TF, Chillemi F. Preparation and isolation of antibodies to human MHC class II alpha chains by aid of synthetic peptides. Z Naturforsch C. 1989 Sep-Oct;44(9-10):813-8. Antibodies against HLA Class II alpha chains were prepared by using as immunogens synthetic peptides selected from the HLA-DQ1 alpha chains sequence. Antibodies raised against peptide E2, a 15-residue fragment of the polymorphic first domain, reacted preferentially with cells with the DQ1 phenotype; however, despite the low sequence homology of this fragment with corresponding segments in DQw2 and DQw3 alpha chains, a partial crossreactivity with cells not expressing the DQw1 specificity was detected. Antibodies to peptide H, selected from the monomorphic frame, might be specific for DQ alloantigens, and presumably do not react with DR antigens. The two peptides, in addition, bind anti-Class II antibodies from the serum of a rabbit immunized with human cells, and appear to represent immunogenic linear determinants in the native glycoprotein molecule.
An informative serum with low MFI values in IgM Luminex assay
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DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04
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View (9)
List of Luminex® HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04,
List of all (Luminex® or not) HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07, DQA1*01:08, DQA1*01:09,
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437 |
61FT
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61F64T55R |
High |
View
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Yes
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61FT on all DQA1 alleles except DQA1*01
61FT was previously named 61FT4.
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ElliPro scores of residues in 61FT4
11Y: 0.147 18S: 0.599 45V: 0.321 48L: 0.201
55R: 0.602 61F: 0.421 64T: 0.499 66I: 0.296 80S: 0.765
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Data from Mélanie DALIGAULT, Laboratoire d’Histocompatibilité, Etablissement Français du Sang –Grenoble, France
The table below shows for 3 patients Luminex assay results with HLA DQ reactivity. The lab used Immucor kits, whose class II single allele panel includes one bead with an unusual DQB-DQA association, DQB1*06 :01-DQA1*02 :01. The positive reaction with this bead, revealed an antibody reactivity pattern towards all non-DQA1*01 alleles, all of which share the DQA eplet 61FT.,
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DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01
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View (20)
List of Luminex® HLA alleles
DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*05:10, DQA1*05:11, DQA1*06:01, DQA1*06:02,
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438 |
66IL
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66I69L |
Intermediate |
View
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DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*05:01, DQA1*05:03, DQA1*05:05
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View (15)
List of Luminex® HLA alleles
DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*05:01, DQA1*05:03, DQA1*05:05,
List of all (Luminex® or not) HLA alleles
DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*05:10, DQA1*05:11,
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439 |
66IT
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66I69T |
Intermediate |
View
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DQA1*04:01, DQA1*06:01
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View (5)
List of Luminex® HLA alleles
DQA1*04:01, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*06:01, DQA1*06:02,
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440 |
75I
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75I161D163I |
High |
View
Click on a Luminex® HLA allele that shares the eplet 75I to view it at pHLA3D
DQA1*01:01,
DQA1*01:02,
DQA1*01:03,
DQA1*01:04,
DQA1*02:01,
DQA1*03:01,
DQA1*03:02,
DQA1*03:03,
DQA1*04:01,
DQA1*06:01,
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DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*06:01
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View (18)
List of Luminex® HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07, DQA1*01:08, DQA1*01:09, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*06:01, DQA1*06:02,
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441 |
75IL
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75I76L |
High |
View
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DQA1*02:01, DQA1*04:01, DQA1*06:01
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View (6)
List of Luminex® HLA alleles
DQA1*02:01, DQA1*04:01, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*02:01, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*06:01, DQA1*06:02,
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442 |
75S
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75S156L161E1... |
High |
View
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Yes
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75S on DQA1*05
This eplet has been previously named 75S3.
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75S represents three eplets defined by distinct polymorphic residues on separate molecular locations: 75S (on the a helix) and 161E and 175K in the membrane-proximal domain. The latter might be less antibody-accessible on DQ molecules attached to cellular membranes.
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Kolstad, A., B. Johansen, et al. (1989). "Two HLA-DQ-specific human-human hybridoma antibodies (TrG6;TrC5) define epitopes also expressed by a transcomplementing hybrid DQ molecule (DQw7 alpha/DQw4 beta)." Human Immunology 24(1): 15-29. Human mAb TrC5 did not react with a DQB epitope as indicated by a lack of blocking competition with DQB-specific antibodies. TrC5 bound to DQw2 of the DQw2+DR3+ haplotype and to DQw7 of the DQw7+DR5+ haplotype. TrC5 recognizes an epitope defined by amino acids at positions 69 and/or 75 of the DQ alpha chain.
Tambur, A., J. R. Leventhal, et al. (2010). "The Complexity of Human Leukocyte Antigen (HLA)-DQ Antibodies and Its Effect on Virtual Crossmatching." Transplantation 90: 1117-1124.Luminex data shows antibody specificity for the 75S3-defined epitope as illustrated by two informative DQ heterodimers: DQA1*05:03/self DQB1*03:01 and DQA1*05:05/self DQB1*03:01
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DQA1*05:01, DQA1*05:03, DQA1*05:05
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View (11)
List of Luminex® HLA alleles
DQA1*05:01, DQA1*05:03, DQA1*05:05,
List of all (Luminex® or not) HLA alleles
DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*05:10, DQA1*05:11,
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442 |
76L
|
76L |
High |
View
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DQA1*02:01, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01
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View (17)
List of Luminex® HLA alleles
DQA1*02:01, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*02:01, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*05:10, DQA1*05:11, DQA1*06:01, DQA1*06:02,
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442 |
76V
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76V26S47Q187T |
High |
View
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Yes
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76V on DQA1*03
Previoulsy named 47QL5, this eplet has a new name (76V); four unique residues may determine three eplets.
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Two sera below had DQA1*03:01 -induced antibodies specific for 76V but the MFI values were
higher with DQA1*03:02 and 1*03:03 alleles which have residue 160D.
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DQA1*03:01, DQA1*03:02, DQA1*03:03
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View (3)
List of Luminex® HLA alleles
DQA1*03:01, DQA1*03:02, DQA1*03:03,
List of all (Luminex® or not) HLA alleles
DQA1*03:01, DQA1*03:02, DQA1*03:03,
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|
442 |
129H
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129H |
High |
View
Click on a Luminex® HLA allele that shares the eplet 129H to view it at pHLA3D
DQA1*01:03,
DQA1*02:01,
DQA1*03:01,
DQA1*03:02,
DQA1*03:03,
DQA1*04:01,
DQA1*05:01,
DQA1*05:03,
DQA1*05:05,
DQA1*06:01,
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DQA1*01:03, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01
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View (19)
List of Luminex® HLA alleles
DQA1*01:03, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*01:03, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*05:01, DQA1*05:03, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*05:10, DQA1*05:11, DQA1*06:01, DQA1*06:02,
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442 |
129QS
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129Q130S |
High |
View
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DQA1*01:01, DQA1*01:02, DQA1*01:04
|
View (7)
List of Luminex® HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:04,
List of all (Luminex® or not) HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:04, DQA1*01:05, DQA1*01:07, DQA1*01:08, DQA1*01:09,
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442 |
130A
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130A |
High |
View
Click on a Luminex® HLA allele that shares the eplet 130A to view it at pHLA3D
DQA1*01:03,
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DQA1*01:03
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View (1)
List of Luminex® HLA alleles
DQA1*01:03,
List of all (Luminex® or not) HLA alleles
DQA1*01:03,
|
|
444 |
160A
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160A |
High |
View
Click on a Luminex® HLA allele that shares the eplet 160A to view it at pHLA3D
DQA1*01:01,
DQA1*01:02,
DQA1*01:03,
DQA1*01:04,
DQA1*02:01,
DQA1*03:01,
DQA1*04:01,
DQA1*05:01,
DQA1*05:05,
DQA1*06:01,
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DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*02:01, DQA1*03:01, DQA1*04:01, DQA1*05:01, DQA1*05:05, DQA1*06:01
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View (21)
List of Luminex® HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*02:01, DQA1*03:01, DQA1*04:01, DQA1*05:01, DQA1*05:05, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:07, DQA1*01:08, DQA1*01:09, DQA1*02:01, DQA1*03:01, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*05:01, DQA1*05:05, DQA1*05:08, DQA1*05:09, DQA1*05:10, DQA1*05:11, DQA1*06:01, DQA1*06:02,
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445 |
160AD
|
160A161D |
High |
View
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DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*02:01, DQA1*03:01, DQA1*04:01, DQA1*06:01
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View (15)
List of Luminex® HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*02:01, DQA1*03:01, DQA1*04:01, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:07, DQA1*01:08, DQA1*01:09, DQA1*02:01, DQA1*03:01, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*06:01, DQA1*06:02,
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|
447 |
160D
|
160D |
High |
View
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DQA1*03:02, DQA1*03:03
|
View (2)
List of Luminex® HLA alleles
DQA1*03:02, DQA1*03:03,
List of all (Luminex® or not) HLA alleles
DQA1*03:02, DQA1*03:03,
|
|
448 |
160S
|
160S |
High |
View
Click on a Luminex® HLA allele that shares the eplet 160S to view it at pHLA3D
DQA1*05:03,
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DQA1*05:03
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View (3)
List of Luminex® HLA alleles
DQA1*05:03,
List of all (Luminex® or not) HLA alleles
DQA1*05:03, DQA1*05:06, DQA1*05:07,
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449 |
175E
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175E |
High |
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DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*06:01
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View (9)
List of Luminex® HLA alleles
DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*06:01,
List of all (Luminex® or not) HLA alleles
DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*04:04, DQA1*06:01, DQA1*06:02,
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